临床病因谱和儿童的功能结果与前状态dystonicus和状态dystonicus (SD):一个描述性的研究
Shridhar P Joshi1, Maya Thomas1, Sangeetha Yoganathan1
1Paediatric Neurology Unit, Departments of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Annals of Indian Academy of Neurology
|August 4, 2023
概括
状态性 (SD) 是一种严重的神经紧急情况,需要住院治疗. 早期识别触发因素和原因对于管理这种情况和改善患者的治疗结果至关重要.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 儿科神经学 儿科神经学
背景情况:
- 状况 dystonicus (SD) 是一种关键的神经紧急情况,其特点是严重的,普遍的 dystonia 情节.
- 它需要紧急住院治疗,并呈现出复杂的临床病因谱,可能导致复发和持久残疾.
研究的目的:
- 划分临床病因谱,诊断结果,治疗策略和儿童患者的后续结果,这些患者经历了前状态性 (SD) 和SD.
主要方法:
- 一项回顾性横截面研究分析了2010年1月至2020年12月期间入院的患有SD前和SD的儿科患者 (<18岁) 的数据.
- 严重程度是使用Dystonia Severity Assessment Plan (DSAP) 尺度进行评估的,结果是使用修改后的兰金尺度 (mRS) 进行评估的.
主要成果:
- 28名患者经历了33次SD发作,平均发病年龄为8.71岁.
- 病因包括代谢性 (威尔逊病),遗传性,结构性,脑后连续性和免疫媒介性原因. 威尔逊病和发烧性疾病是常见的触发因素.
- 大多数患者需要进行米达佐拉姆输液,并经历了残留性 dystonia;三名患者死于耐火性SD.
结论:
- 快速识别触发因素和病因对于有效管理SD至关重要.
- 及时和适当的干预对于减轻这种危及生命的运动障碍紧急情况的严重程度和并发症至关重要.
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