2014-2022年口服抗凝剂的补偿和使用 - - 基于注册的研究
Emma Aarnio1,2, Risto Huupponen2, Janne Martikainen1
1School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Exploratory research in clinical and social pharmacy
|August 4, 2023
概括
芬兰的直接口服抗凝剂 (DOAC) 使用量从2014年到2022年大幅增加,超过了华法林. 随着DOAC的报销政策变得不那么严格,这一趋势加速了,尽管与其他国家相比,最初的采用速度较慢.
科学领域:
- 药理学 药理学是指药理学的学科.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 维生素K对抗剂,主要是华法林,是标准的抗凝疗法.
- 直接口服抗凝剂 (DOACs) 的引入导致全球华法林使用量下降.
- 了解口服抗凝剂 (OAC) 的趋势对于管理诸如心房动 (AF) 等疾病至关重要.
研究的目的:
- 分析芬兰口服抗凝剂 (OAC) 的使用趋势.
- 评估DOAC补偿政策和国家AF治疗指南对OAC使用的影响.
- 为了比较随着时间的推移,DOACs与华法林的吸收.
主要方法:
- 利用了有关OAC退款 (2014-2022) 的综合公共数据.
- 用于详细分析 (2014-2022) 的个人级别电子处方数据.
- 使用2015-2016年的数据检查了OAC启动,并跟踪了DOAC退款资格.
主要成果:
- DOAC用户从2014年的20,000人升到2022年的214,000人.
- 华法林使用者从2015年的超过181,000人下降到2022年的约59,000,DOAC在2019年超过了华法林.
- 从2019年到2022年,阿皮克萨班成为最常用的DOAC,而DOAC的启动在2016年超过了华法林.
- 对DOAC,特别是对AF的补偿资格稳步增加,到2022年达到超过196,000人.
结论:
- 芬兰的DOAC采用是渐进的,比许多其他国家慢.
- 与欧洲建议相比,国家AF治疗指南最初对DOACs更为保守.
- 增加的DOAC使用与不那么严格的退款政策相关联.
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