在艾滋病毒感染者中,谁有新的乙型肝炎感染的风险?
John M Sladic1, Barbara S Taylor1, Mae Thamer2
1University of Texas Health Science Center, San Antonio, Texas, USA.
Open forum infectious diseases
|August 4, 2023
概括
乙型肝炎病毒 (HBV) 感染仍然是艾滋病毒感染者 (PWH) 的担忧. 新的HBV感染表明,在这个人群中,疫苗接种和治疗有效性的差距很大.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染对健康构成重大风险,增加了艾滋病毒感染者 (PWH) 的发病率和死亡率.
- 同时感染HBV和HIV使疾病管理和治疗结果复杂化.
研究的目的:
- 为了确定艾滋病毒感染者队列中新型乙型肝炎病毒感染的发生率.
- 确定当前HBV预防策略的潜在缺口,包括疫苗接种和抗逆转录病毒疗法 (ART).
主要方法:
- 对HBV发病率的回顾性分析.
- 将5785名艾滋病毒感染者纳入研究队列.
- 追踪新阳性乙型肝炎表面抗原 (HBsAg) 的结果,平均随访期为5.2人年.
主要成果:
- 确定了14例新诊断的HBV感染病例.
- 新HBV感染的发病率计算为每10万人/年46.4.
- 这些发现表明,在研究的PWH队列中,对HBV的保护不足.
结论:
- 在艾滋病毒感染者中,B型肝炎病毒疫苗接种覆盖率和有效性存在显著差距.
- 目前针对HBV特定的抗逆转录病毒疗法方案的预防性疗效需要在这个人群中进一步评估.
- 加强HBV预防和管理策略对于改善艾滋病毒感染者的健康结果至关重要.
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