急性缺血性中风患者与左心房扩大患者的特定炎症特征
Julia Fontaine1, Simon Leboube2,3, Thomas Bochaton2,3
1Stroke Department, Hospices Civils de Lyon, Bron, France.
Frontiers in cardiovascular medicine
|August 4, 2023
概括
在急性缺血性中风 (AIS) 患者中,左心房扩大 (LAE) 与较高水平的血管细胞粘附分子-1 (VCAM-1) 和可溶性形式抑制瘤性 2 (sST2) 相关. 这些炎症标志物可能表明LAE的AIS中炎症反应加剧.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 大心肌病的炎症过程可能会影响急性缺血性中风 (AIS) 的炎症反应.
- 左心房扩大 (LAE) 作为心房肌病的标志物.
研究的目的:
- 在AIS患者中调查LAE和循环炎症标志物之间的关联.
- 为了确定LAE是否与AIS中的独特炎症概况有关.
主要方法:
- 一项对AIS患者进行机械血栓切除治疗的队列研究 (HIBISCUS-STROKE).
- 在入院后48小时内测量了10种循环炎症标志物.
- 使用左心室体积指数 (LAVi ≥34毫升/m2) 定义LAE.
- 多重逻辑回归分析,以评估曲线下的炎症标记面积 (AUC) 和LAE之间的关联.
主要成果:
- 在143名患者中,有85名患者 (59.4%) 呈现LAE.
- 患有LAE的患者显示,可溶性形式抑制瘤性2 (sST2),可溶性瘤缩因子受体I (sTNFR1) 和血管细胞粘附分子-1 (VCAM-1) 的AUC更高.
- 多变量分析发现高VCAM-1 (OR:9.13) 和sST2 (OR:3.40) AUC与LAE独立相关.
结论:
- 在48小时内升高的VCAM-1和sST2水平与AIS患者的LAE有关.
- 这些发现表明,LAE的AIS患者具有特定的炎症特征.
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