微生物代谢物在糖尿病病中的作用
Ting Zhu1, Bi-Ying Hu2, Yi-Qing Zhang1
1Department of Nephrology, Center of Kidney and Urology, the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Heliyon
|August 4, 2023
概括
糖尿病病 (DKD) 与肠道微生物的变化有关. 这项研究发现肠道微生物代谢物发生变化,如乙和血清素,并扰乱了DKD小鼠的脂质代谢,表明肠-轴连接.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肠-轴突出了肠道微生物群,微生物代谢物和糖尿病病 (DKD) 之间的双向相互作用.
- 了解微生物代谢物在DKD病变发生过程中的特定作用至关重要.
研究的目的:
- 在DKD的背景下调查微生物代谢物的变化.
- 描述与DKD进展相关的代谢特征变化.
主要方法:
- 使用液体色谱与双重质谱 (LC-MS/MS) 基于代谢分析.
- 分析了db/db (DKD模型) 和db/m (对照) 小鼠的血清,尿液,便,肝脏,周脂肪和脏样本.
- 将DKD和对照组之间的代谢概况进行比较.
主要成果:
- 与db/m小鼠相比,db/db小鼠表现出显著的病理和功能受损.
- 在脏组织中观察到甲 (IAld) 和5--l-三 (5-HTP) 的水平升高,在db/db小鼠的便样本中观察到血清素 (5-HT).
- 在db/db小鼠的肝脏,血清,脏和周周脂肪中观察到酸丁 (PC),酸丁 (PA) 和1-酸甘油 (lysoPC) 的水平降低,这表明甘油脂代谢受损.
结论:
- DKD与肠道微生物代谢的显著扰乱有关,特别是在托和甘氨酸脂通路中.
- 这些发现支持肠-轴理论,并建议在肠道微生物组内用于DKD治疗的潜在治疗点.
相关概念视频
01:25Chronic Kidney Disease I: Introduction
36
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
36
01:24Chronic Kidney Disease II: Clinical Manifestations
30
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
30
01:28Chronic Kidney Disease III: Interprofessional Care
42
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
01:40Overview of Metabolism
31.1K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
31.1K
01:20Renal Corpuscle
2.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.6K
01:20Pathophysiology of Diabetes
989
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
989