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确定ALG3作为肺腺癌的潜在预后生物标志物

Yinjiao Yuan^1,2, BaoCheng Xie³, Dongbo Guo⁴

¹The First School of Chinical Medicine, Southern Medical University, Guangzhou, 510510, China.

|August 4, 2023

概括

高表达的α-1,3-mannosyltransferase (ALG3) 与肺腺癌 (LUAD) 的预后不佳相关. 这项研究揭示了ALG3与免疫透物之间的关联以及其作为诊断标记物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

异常的α-1,3-mannosyltransferase (ALG3) 表达与瘤促进有关.
在肺腺癌 (LUAD) 中ALG3的临床作用尚不清楚.

研究的目的:

为了研究ALG3在LUAD中的预后价值.
探索ALG3表达和LUAD中的免疫透物之间的关联.

主要方法:

使用TCGA数据在LUAD中分析ALG3表达.
用Kaplan-Meier,Cox回归和ROC分析进行预后和诊断评估.
通过TIMER和TISIDB数据库调查ALG3与免疫细胞的相关性.
进行了体外实验,以评估ALG3对癌症干和信号通路的影响.

主要成果:

与正常组织相比,LUAD组织中观察到ALG3mRNA和蛋白质水平升高.
高ALG3表达与先进的N阶段,病态阶段和吸烟史有显著的相关性.
过度表达ALG3与较差的整体存活率,无病存活率和无进展间隔有关.
ALG3表达与瘤透免疫细胞有显著联系,并作为可靠的诊断标记物 (AUC:0.923).
ALG3与FAT4负相关,抑制了癌症干,并抑制了YAP/TAZ信号通路.

结论:

高ALG3表达是LUAD预后不佳的重要指标.
ALG3与免疫细胞透有关,可以作为LUAD的诊断生物标志物.

关键词:

ALG3 ALG3 在线免疫系统的透.肺部腺癌瘤是肺部腺癌.预测生物标志物预测生物标志物

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...