血清激素通过增强ON而不是OFF类型感觉神经元的反应来增加行为相关刺激的种群编码
Mariana M Marquez1, Maurice J Chacron1
1Department of Physiology, McGill University, Canada.
Heliyon
|August 4, 2023
概括
神经调节对电鱼的神经群体产生不同影响,增强感官处理. 这种在ON型细胞中的选择性增强,而不是OFF型细胞,与对相关刺激的改善行为反应相关.
科学领域:
- 系统神经科学 系统神经科学
- 神经伦理学 神经伦理学
- 感官处理 感官处理
背景情况:
- 了解神经群体如何为行为编码感官信息是一个关键的挑战.
- 神经调节在塑造神经群体代码对行为相关刺激的作用尚未完全理解.
研究的目的:
- 研究拉菲核刺激的神经调节如何影响 *Apteronotus leptorhynchus* 的电感系统中的种群编码.
- 为了确定神经群体编码和行为反应的变化之间的关系.
主要方法:
- 在启动和关闭感官金字塔细胞上进行了多单元记录.
- 使用了具有时间变化的振幅包裹的刺激.
- 在对拉菲核进行电刺激之前和之后进行了记录.
主要成果:
- 拉菲刺激增加了ON型细胞的种群编码,但不是OFF型细胞.
- 单个神经元对刺激的敏感性在ON和OFF细胞之间是相似的.
- 在ON型细胞的种群编码的变化,但不是OFF型细胞,与行为反应变化相关.
结论:
- 神经调节不同地影响ON和OFF类型的感觉细胞.
- 这种差分调制增强了对行为相关感官输入的感知.
- 选择性增强ON型细胞群编码对于行为输出至关重要.
相关概念视频
Excitatory and Inhibitory Effects of Neurotransmitters
10.1K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
10.1K
Synaptic Signaling
75.1K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
75.1K
Human Genetics
612
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
612
Neurochemical Transmission: Sites of Drug Action
2.5K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.5K
Sympathetic Signaling
1.0K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
1.0K
Somatosensation
36.7K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.7K


