对自闭症谱系障碍患者抗精神病药物的随机对照试验:系统性审查和元分析
Shoumitro Deb1, Meera Roy2, Bharati Limbu1
1Department of Brain Sciences, Faculty of Medicine, Imperial College London, 2nd Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK.
Psychological medicine
|August 4, 2023
概括
抗精神病药物可以改善自闭症儿童的易怒性,但会增加副作用. 没有精神疾病的自闭症长期使用的证据尚不清楚,风险超过成年人的益处.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 抗精神病药物的使用在自闭症患者的问题行为中很常见,尽管长期有效性的证据有限,但没有同时发生的精神疾病.
- 当前的做法往往忽略了缺乏可靠的数据,支持在这个人群中持续使用抗精神病药物治疗.
结论:
- 里斯佩里在患有自闭症的儿童中显示了一些益处的证据,阿里皮普拉显示了初步证据,但对于成年人或其他抗精神病药物来说没有.
- 与抗精神病药物相关的不良影响的明显增加与其在自闭症患者中的使用有关.
- 这些研究结果表明,对于自闭症患者的行为问题,对抗精神病药物处方有谨慎的做法,特别是关于长期使用和潜在的副作用.
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