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Updated: Jul 20, 2025

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
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结合预测和分析方法,阐明活性污泥中的制药生物转化

Leo Trostel1, Claudia Coll1, Kathrin Fenner1,2

  • 1Department of Environmental Chemistry, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, 8600, Zürich, Switzerland. kathrin.fenner@eawag.ch.

Environmental science. Processes & impacts
|August 4, 2023
PubMed
概括

科学家们开发了一种自动化工作流程,以识别生物降解中的制药转化产品 (TP). 这种方法成功地确定了31种药物的79个TP,改善了环境监测和化学风险评估.

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
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