COVID-19与患有高血糖危机的儿童疾病严重程度之间的关联
Vanessa Toomey1,2, Margret J Klein1, Alaina P Vidmar3,4
1Department of Anesthesiology and Critical Care, Children's Hospital of Los Angeles, Los Angeles, California.
Hospital pediatrics
|August 4, 2023
概括
在COVID-19大流行期间,儿科高血糖危机 (HGC) 的入院增加了严重程度. 这一趋势持续了两年,表明HGC儿童的重症监护需求持续增加.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 关键护理医学 关键护理医学
- 传染病流行病学 传染病流行病学
背景情况:
- COVID-19大流行与儿科高血糖危机 (HGC) 的ICU入院人数增加有关.
- HGC包括糖尿病酸性脂肪酸症,高血糖性超大综合征和超大酸性脂肪酸症.
研究的目的:
- 为了确定儿童高血糖危机 (HGC) 的严重程度是否从大流行前期增加到COVID-19大流行的前两年.
- 分析疫情期间儿科HGC的ICU入院和其他重症监护结果的趋势.
主要方法:
- 一项回顾性研究分析了2017年3月至2022年2月期间住院治疗HGC的儿童 (≤18岁) 的数据.
- 在COVID-19之前的年份 (2017年3月至2020年2月) 与COVID-19第一年 (2020年3月至2021年2月) 和第二年 (2021年3月至2022年2月) 相比较.
- 主要结局是ICU入院;次要结局包括死亡率,停留时间,成本和需要机械通风或血管活性支持.
主要成果:
- 在46,425名HGC入院患者中,43.2%的患者进入了ICU.
- 在COVID-19年1 (OR 1.31) 和年2 (OR 1.17) 期间入院的儿童与大流行前相比,ICU入院的几率明显更高.
- 虽然一些次要结局表明严重程度增加,但这些关联不一致,死亡率没有差异.
结论:
- 在COVID-19大流行期间,患有HGC的儿科患者的疾病严重程度增加,这一趋势持续了两年.
- 诸如社交距离措施和SARS-CoV-2变体等因素并没有显著改变HGC和加大ICU护理要求之间的联系.
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