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麻症增加肝移植死亡风险:系统性审查和元分析

Konstantinos Prokopidis^1,2, Marco Affronti³, Giuseppe D Testa⁴

¹Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Panminerva medica

|August 4, 2023

概括

肉症是一种肌肉损失的疾病,对肝移植候选人的死亡风险显著增加一倍. 早期干预治疗肉类可能会改善这一患者群的生存率.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
老年医学老年医学

背景情况:

肝硬化症的许多患者需要移植.
肝移植接受者的萨尔科佩尼亚的预后影响仍然不清楚.
这项研究探讨了萨科佩尼亚在肝移植结果中的未知作用.

研究的目的:

系统地审查和元分析萨科佩尼亚对肝移植患者死亡率的影响.
在这个人群中量化与肉类相关的死亡风险.

主要方法:

系统地搜索多个数据库 (开始2022年12月) 进行观测研究.
对肉患者与非肉患者的死亡率调整后风险比率 (RRs) 的元分析.
使用随机效应模型进行数据合成.

主要成果:

包括33项研究,涉及12,137名患者 (平均年龄为55.3岁).
萨科佩尼亚与死亡风险增加约2倍相关 (RR:2.01;95% CI:1.702.36).
对死亡率调整后的RR,考虑到出版偏差,为1.75 (95% CI:1.492.06).

结论:

麻症与肝移植候选人的死亡风险增加有显著的关联.
强调需要进行针对这种人群的 Sarcopenia 逆转的干预研究.
这些干预措施可以降低接受肝移植的患者的死亡风险.

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