探索人类微生物组 - - 对于乳腺癌的精准医学来说,这是一个前进的步骤
Asmita Jotshi1, Krishna Kishore Sukla2, Mohammed Monzoorul Haque2
1Centre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM), Pune, India.
Cancer reports (Hoboken, N.J.)
|August 4, 2023
概括
肠道微生物组的改变 (失生症) 影响乳腺癌的发展和结果. 了解瘤生物组为预防和个性化乳腺癌治疗提供了新的途径.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 乳腺癌是全球主要的恶性瘤,特别影响女性,印度的死亡率很高.
- 早期发病和高死亡率与发病率的比率凸显了改善乳腺癌管理策略的迫切需要.
研究的目的:
- 审查肠道微生物群和微生物失生症对乳腺癌发生的影响.
- 探索瘤生物组和乳腺癌分子亚型之间的相互作用.
- 讨论饮食,表观遗传学和技术进步在乳腺癌微生物组研究中的作用.
主要方法:
- 关于肠道微生物群和乳腺癌的最新研究的文献综述.
- 分析微生物失生症,表观遗传学和饮食之间的相互作用.
- 在微生物组分析中评估先进技术,如下一代测序 (NGS) 和人工智能 (AI).
主要成果:
- 肠道微生物群显著影响乳腺癌的发展,治疗反应和预后.
- 微生物失生症与乳腺癌的发生和特定的分子亚型有关.
- 饮食和表观遗传学调节肠道微生物群,影响乳腺癌的预防和复发.
结论:
- 关联微生物组和致癌发生对于理解癌症机制至关重要.
- 微生物组有可能成为乳腺癌预后的生物标志物.
- 准微生物组可能会导致乳腺癌的新型个性化治疗策略.
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