对树和橄花粉过敏:临床表型和过敏原识别
M D Alonso-Díaz de Durana1, E Pérez-Fernández2, M Villalba3
1Allergy Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Journal of investigational allergology & clinical immunology
|August 4, 2023
概括
双树和橄过敏是由于对Cup s 1和Ole e 1的敏感引起的,而树花粉中的类似蛋白质具有交叉反应. 这导致过敏犀牛结膜炎和喘有四种不同的临床表型.
科学领域:
- 过敏原免疫疗法免疫疗法
- 临床免疫学 临床免疫学
- 分子过敏学分子过敏学
背景情况:
- 树和橄花粉是地中海地区常见的过敏原.
- 越来越多地认识到对树和橄花粉的双重敏感性.
- 了解双重敏感性对于准确的诊断和治疗至关重要.
研究的目的:
- 确定导致双树和橄过敏 (C+O) 的特定过敏原.
- 研究C+O患者的临床症状和过敏原敏感化概况之间的关系.
- 描述与C+O相关的不同的临床表型.
主要方法:
- 患者选择:C+O患者和单一敏感的对照.
- 过敏原检测:针对整个提取物和净化过敏原的特定IgE.
- 免疫学测定:IgE和IgG结合的免疫结合.
- 交叉反应性分析:用花粉提取物和过敏原进行抑制试验.
- 数据分析:多重对应分析和层次聚类.
主要成果:
- 确定了四种不同的C+O过敏的临床表型.
- 最常见的表型涉及犀牛结膜炎 (冬季/春季),喘的发生率很高.
- 确定Ole e 1 (橄) 和Cup s 1 () 是主要的过敏原.
- 在树花粉中发现了与橄油过敏原 (Ole e 1, 9, 11) 相同的蛋白质,表明了交叉反应性.
结论:
- 双树和橄过敏是由于对Ole e 1和Cup s 1的共同敏感性引起的.
- 交叉反应是由树花粉过敏原介导的,类似于已知的橄过敏原.
- 四种临床表型,包括多年或季节性犀牛结膜炎,喘或没有喘,与C+O过敏有关.
相关概念视频
02:06Allergic Reactions
27.8K
Overview
27.8K
00:42Cross-reactivity
31.3K
Overview
31.3K
01:30Hypersensitivities
739
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
739
01:27Allergic Drug Reactions
876
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
876
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
346
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
346