脊椎骨评分作为一种更敏感的工具,用于评估与MEN1相关的原发性甲状腺功能障碍症相关的骨干参与
An Song1, Rong Chen1, Wenmin Guan2
1Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
The Journal of clinical endocrinology and metabolism
|August 4, 2023
概括
多发性内分泌瘤1型相关甲状腺功能障碍症 (MHPT) 患者比零星性甲状腺功能障碍症 (SHPT) 患者表现出更严重的骨损伤,即使骨矿物质密度 (BMD) 正常. 脊椎骨评分 (TBS) 可以识别MHPT中的这种骨微观结构损伤.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是一门学科.
背景情况:
- 在一次性甲状腺功能障碍的骨参与不同于多重内分泌瘤1型相关 (MHPT) 和零星 (SHPT) 形式.
- 脊椎骨评分 (TBS) 是一种质地参数,反映了脊椎骨损伤.
研究的目的:
- 为了比较MHPT和SHPT患者之间的临床特征和骨参与.
- 评估TBS在评估MHPT骨健康方面的实用性.
主要方法:
- 对120名MHPT患者和360名SHPT患者的回顾性分析.
- 双能X射线吸收计 (DXA) 用于骨矿物密度 (BMD) 和TBS计算从腰椎图像.
主要成果:
- 尽管疾病持续时间较长,但MHPT患者在住院访问时更年轻.
- 整体而言,MHPT中骨参与较少,但在年龄和性别相匹配时类似.
- 与SHPT患者相比,MHPT患者的腰椎下部骨质硬化和TBS.
- 在34名MHPT患者中,TBS在15名正常的BMD患者中发现了骨微结构损伤.
结论:
- 正如TBS所指出的那样,MHPT患者的癌骨微架构受到更严重的损伤.
- TBS是BMD的敏感补充指数,用于识别MHPT中的骨参与风险.
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