在状细胞疾病患者中治疗慢性病的干预措施
Noemi Ba Roy1, Abigail Carpenter2, Isabella Dale-Harris3
1Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
The Cochrane database of systematic reviews
|August 4, 2023
概括
有限的证据表明,氨酸可能会改善状细胞疾病 (SCD) 的儿童的尿度,但其对病进展的影响尚不确定. 需要对诸如基尿素和ACE抑制剂等干预措施进行更多的研究,以预防SCD患者的脏并发症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
背景情况:
- 状细胞疾病 (SCD) 是一种严重的单一性疾病,具有显著的末端器官损伤,包括频繁的脏并发症 (状细胞脏病).
- 慢性病的慢性病 (CKD) 可以发展为末期病,影响到12%的受影响人群.
- 在SCD中,早期的淋巴细胞损伤和小蛋白尿是常见的,随着年龄的增长而增加.
结论:
- 目前关于状细胞病的干预措施的证据有限,确定性低至非常低.
- 迫切需要更多高质量的RCT来评估素尿素,ACEI和红细胞输血,以预防SCD中的并发症.
- 需要进一步的研究来指导SCD和不同基因型的老年儿童和成人的管理.
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