在COVID-19疫苗接种后的耳鼻喉副作用
Salma Ahsanuddin1, Ryan Jin2, Aatin K Dhanda2
1Department of Otorhinolaryngology - Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
接种COVID-19疫苗导致耳鼻喉学不良事件,有明显的发现是味道和气味的改变,喉症状,耳和头. 大多数其他报告的耳鼻喉副作用都没有临床意义.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 广泛的COVID-19疫苗接种引发了对潜在不良事件 (AE) 的担忧.
- 耳鼻喉 (耳鼻喉) 副作用是需要调查的副作用之一.
- 了解这些副作用的频率和重要性对于公共卫生和疫苗信心至关重要.
研究的目的:
- 评估COVID-19疫苗接种后耳鼻喉学不良事件的发生频率.
- 将这些副作用的发生率与其他疫苗报告的发生率进行比较.
- 为了确定特定的耳鼻喉学AE,这些AE在接种疫苗后具有临床意义.
主要方法:
- 国家疫苗不良事件报告系统 (VAERS) 数据库的回顾性分析.
- 从2020年12月到2021年5月收集的数据,包括Moderna,Pfizer-BioNTech和Janssen的COVID-19疫苗.
- 耳鼻喉病情被分类,报告几率比率 (ROR) 和比例报告比率 (PRR) 为临床显著的AE计算.
主要成果:
- 在报告的1,280,950次副作用中,62,660次 (4.9%) 是耳鼻喉病.
- 显著的信号比率被观察到对于dysgeusia,ageusia, anosmia,鼻,喉紧张,喉刺激,消化不良,耳和头.
- 面部,贝尔,过敏反应,鼻炎,听力障碍和耳朵疼痛没有达到显著性值.
结论:
- 虽然在COVID-19疫苗接种后报告了几种耳鼻喉症状,但很少达到临床意义.
- 诸如味觉/嗅觉障碍,喉刺激,耳和头等特定症状的报告比例显著.
- 该研究提供了有关耳鼻喉学不良事件的COVID-19疫苗安全概况的宝贵数据.
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