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疲劳调解了儿童癌症治疗后情绪和认知功能之间的关系
Juliette E M Greidanus-Jongejan1, Marloes van Gorp1, Raphaele R L van Litsenburg1
1Department of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Pediatric blood & cancer
|August 4, 2023
概括
接受癌症治疗的儿童往往会出现认知问题. 这项研究发现,疲劳调解了这些儿童的情绪和认知功能之间的联系,强调疲劳是关键的干预目标.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经心理学 神经心理学
- 康复医学 康复医学 康复医学
背景情况:
- 接受癌症治疗的儿童患有认知障碍的风险增加.
- 了解情绪,认知和疲劳症状之间的相互作用对于开发有效的干预措施至关重要.
- 以前的研究表明,有必要在儿童癌症幸存者中探索这些关联.
研究的目的:
- 评估癌症治疗后儿童的情绪功能,疲劳和认知功能.
- 调查疲劳在这种人群中情绪和认知功能之间的关系中扮演的调解角色.
主要方法:
- 使用经过验证的尺度 (PedsQL,多维疲劳尺度,认知功能尺度) 评估情绪功能,疲劳和认知功能.
- 儿童癌症幸存者的结果与一般人口同龄人的结果进行了比较,使用单样品t测试.
- 使用调解分析来检查疲劳对情绪-认知功能联系的间接影响.
主要成果:
- 与同龄人 (p < .001) 相比,儿童癌症幸存者表现出明显较低的情绪功能 (d = 0.4),更高的疲劳 (d = 0.8),以及降低的认知功能 (d = 0.6).
- 在情绪和认知功能之间观察到显著的关联 (β=0.27,p < .001).
- 发现疲劳调解了这种关系 (β=0.16),这表明它在将情绪状态与认知表现联系起作用.
结论:
- 癌症治疗后的儿童表现出情绪和认知功能受损,加上疲劳水平升高.
- 疲劳在儿童癌症幸存者的情绪和认知功能之间发挥着重要的调解作用.
- 针对疲劳管理对于改善正在接受或正在完成癌症治疗的儿童的认知结果至关重要.
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