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系统性硬化症的临床特征和过程与血清中白蛋白-8,血管内皮生长因子,基本纤维细胞生长因子和干扰素α之间的关联

Joanna Kosałka-Węgiel^1,2, Sabina Lichołai², Sylwia Dziedzina²

¹Department of Rheumatology and Immunology, Jagiellonian University Medical College, Kraków, Poland.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

|August 4, 2023

概括

与对照组相比,全身性硬化症 (SSc) 患者的基本纤维细胞生长因子 (bFGF) 和干扰素α (IFN-α) 的血清水平较高. 血管内皮生长因子 (VEGF) 和IFN-α的升高与癌症风险相关,而增加的互白素-8 (IL-8) 表示死亡风险更高.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
在瘤学瘤学.

背景情况:

系统性硬化症 (SSc) 的发病包括可溶性生长因子和细胞因子等媒介.
了解这些调解者对于管理SSc及其并发症至关重要.

研究的目的:

在SSc患者中,研究血管内皮生长因子 (VEGF),介质素-8 (IL-8),干扰素α (IFN-α) 和基本纤维细胞生长因子 (bFGF) 的血清水平之间的关联.
为了将这些细胞因子水平与SSc临床表现,疾病过程以及癌症和死亡率等结果相关联.

主要方法:

一项纵向的观察性研究,涉及43名SSc患者和24名健康对照.
在基线测量血清细胞因子度 (VEGF,IL-8,IFN-α,bFGF).
病史和5年随访期间对死亡和癌症发病率进行回顾性分析.

主要成果:

与对照组相比,SSc患者的bFGF和IFN-α血清度显著更高.
增加的VEGF和IFN-α水平与增加的环胺使用和更高的癌症发病率有关.
较高的IL-8水平与死亡风险增加有关,IL-8/bFGF与口服类固醇剂量相关.

结论:

SSc的特点是血清bFGF和IFN-α的升高.
特定的细胞因子概况 (VEGF,IFN-α,IL-8) 可能作为SSc患者癌症风险和死亡率的生物标志物.
需要进一步的研究来验证这些发现及其临床影响.

关键词:

基本的纤维细胞生长因子干扰素α是干扰素α的一种.介质蛋白-8-8的使用方法系统性硬化症系统性硬化症血管内皮生长因子血管内皮生长因子

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