火焰 (v2.0):来自多个来源的功能丰富结果的高级集成和解释
Evangelos Karatzas1, Fotis A Baltoumas1, Eleni Aplakidou1
1Institute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari (Athens), 16672, Greece.
Bioinformatics (Oxford, England)
|August 4, 2023
概括
Flame (v2.0) 通过集成多种工具和提供高级可视化来增强功能丰富分析. 这个网络工具支持超过14000种生物和各种输入选项,用于全面的基因和蛋白质分析.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 功能丰富分析从基因或蛋白质列表中识别生物功能.
- 现有的工具往往提供孤立的结果,限制了全面的解释.
研究的目的:
- 为了介绍火焰 (v2.0),一个增强的网络工具,用于组合功能丰富分析.
- 整合和可视化来自多个广泛使用的丰富应用程序的结果.
主要方法:
- 火焰 (v2.0) 将aGOtool,g:Profiler,WebGestalt和Enrichr.的输出合并在一起.
- 它使用视觉分析与互动图像,如网络,热图和UpSet图.
- 支持用于基因/蛋白质提取,SNP分析和火山情节集成的文本挖掘.
主要成果:
- 火焰 (v2.0) 提供灵活的输入选项,并支持14436个生物体,与之前的版本相比大幅增加.
- 提供来自多个管道的综合和可视化结果,以方便解释.
- 能够同时分析多个基因/蛋白质列表和差异表达数据.
结论:
- Flame (v2.0) 提供了一个强大的,用户友好的平台,用于先进的功能丰富分析.
- 它的组合方法和广泛的生物支持有助于更深入的生物学见解.
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