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Josje H E Arts1, Frank Faulhammer2, Steffen Schneider3

  • 1Nouryon Functional Chemicals B.V., Deventer, The Netherlands.

Critical reviews in toxicology
|August 4, 2023
PubMed
概括

欧洲化学品局 欧洲化学品局

关键词:
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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...