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Updated: Jul 20, 2025

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
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Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

Published on: January 6, 2017

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CoCoNat:一种基于深度学习的新方法,用于线圈-线圈预测

Giovanni Madeo1, Castrense Savojardo1, Matteo Manfredi1

  • 1Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Italy.

Bioinformatics (Oxford, England)
|August 4, 2023
PubMed
概括

CoCoNat准确地预测了卷轴-卷轴域 (CCD) 边界,残留物注册表和寡合化状态. 这种新的深度学习方法超越了CCD计算检测和功能注释的当前最先进的工具.

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
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