在克罗恩病患者中验证肠急性数值评分表:来自混合方法研究的结果
Marla C Dubinsky1, Laure Delbecque2, Theresa Hunter3
1Pediatric GI and Nutrition, Icahn School of Medicine- Mount Sinai Hospital, New York City, NY, USA.
肠急性 (BU) 是克罗恩病 (CD) 的一个显著症状. 紧急数值评分表 (NRS) 现在已被验证为测量CD患者BU严重性的可靠工具.
科学领域:
- 胃肠病学 胃肠病学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 肠急性 (BU) 是克罗恩病 (CD) 的普遍且具有影响力的症状.
- 目前,没有经过验证的患者报告结果 (PRO) 尺度专门评估CD患者的BU严重程度.
- 评估BU对于管理CD和改善患者生活质量至关重要.
研究的目的:
- 评估紧急数值评分表 (NRS) 的内容有效性和心理特征.
- 建立紧急NRS作为测量CD患者BU严重性的可靠工具.
主要方法:
- 与中度至重度的CD参与者进行定性访谈,以评估BU的相关性和汇报紧急NRS.
- 认知汇报探讨了分数解释和CD缓解标准.
- 一项定量网络调查评估了紧急NRS的测量特性.
主要成果:
- 在35名参与者中,有34人报告BU,显著影响日常活动.
- 患者证实了紧急NRS的相关性,适当性和可理解性.
- 紧急NRS在定量调查中证明了可接受的测试复试可靠性和强大的有效性.
结论:
- 紧急NRS是一种有效和可靠的工具,用于评估克罗恩病中肠急症的严重程度.
- 这种经过验证的尺度可以帮助临床医生监测BU和CD患者的治疗有效性.
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