脑小脑对异常精神运动功能的影响是由精神病频谱中的处理速度介导的
Alexandra B Moussa-Tooks1, Jinyuan Liu2, Kristan Armstrong3
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, Nashville, TN, 37212, USA. amoussat@iu.edu.
Cerebellum (London, England)
|August 4, 2023
概括
精神病中的精神运动障碍通过处理速度与小脑功能有关. 这项研究揭示了小脑灰质体积如何影响处理速度,这反过来又影响了患者的精神运动症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神运动障碍是精神病的核心特征,影响超过66%的无药治疗的第一发病患者.
- 小脑异常与感觉运动缺陷有关,包括处理速度,在精神病中可能是潜在的精神运动障碍.
- 确切的脑 - 行为 - 症状关系,特别是考虑到诊断异质性,仍然不清楚.
研究的目的:
- 调查处理速度在小脑灰质体积和精神病中精神运动障碍之间的关系中扮演的调解角色.
- 研究小脑传感运动网络完整性与精神分裂症和双相情感障碍患者的处理速度和精神运动症状的关系.
主要方法:
- 在339名精神病患者和217名对照中利用神经影像 (大脑小灰质体积) 和神经心理测试 (处理速度).
- 通过积极和消极综合征量表 (PANSS) 评估精神运动障碍,通过SCIP评估处理速度.
- 采用调解模型,控制内体积,年龄,性别和药物 (罗马等价物).
主要成果:
- 通过处理速度观察到显著的中介.
- 小小脑灰质体积对处理速度的微小积极影响 (ß = 0.172,p = 0.029).
- 处理速度对精神运动障碍的中等负面影响 (ß = -0.254,p < 0.001),表明处理速度较慢会加剧精神运动症状.
结论:
- 小脑电路在处理与精神病相关的速度缺陷方面发挥着关键作用.
- 处理速度作为一个关键的媒介,将小脑功能与精神疾病中的精神运动现象联系起来.
- 研究结果支持针对性干预措施的开发,例如对精神病相关的感觉运动障碍的跨磁刺激 (TMS).
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