治疗后早期的MRI预测了肝细胞癌对辐射细分切除术的长期反应
Daniel Stocker1,2, Michael J King3, Maria El Homsi3
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. daniel.stocker@usz.ch.
European radiology
|August 4, 2023
概括
在90辐射细分切除术后的早期MRI准确地预测了肝细胞癌 (HCC) 患者的长期反应. 像mRECIST和LI-RADS TRA这样的标准化标准显示了完全响应的高正预测值.
科学领域:
- 肝胆道成像检查 肝胆道成像检查
- 干预性瘤学 干预性瘤学
- 放射学 放射学是一门学科.
背景情况:
- 肝细胞癌 (HCC) 管理越来越多地使用伊-90辐射细分切除术.
- 治疗后早期对治疗反应的评估至关重要,但辐射断片切除术后的价值尚不清楚.
研究的目的:
- 评估早期治疗后MRI在预测HCC患者接受辐射分片切除术的长期治疗反应中的有效性.
- 为了比较不同响应评估标准的性能.
主要方法:
- 对80名HCC患者的回顾性分析,这些患者在辐射细分切除术前,早期和12个月后接受了对比度增强的MRI.
- 三名放射科医生使用mRECIST,LI-RADS治疗响应算法 (TRA) 和图像减法评估了病变反应.
- 12个月的长期反应是主要终点;计算了预测完整反应 (CR) 的诊断准确性.
主要成果:
- 在12个月后,92.5%的患者实现了CR.
- 早期的MRI评估在预测CR时表现出相当准确的准确性.
- 所有评估的标准 (mRECIST,LI-RADS TRA,减法) 显示出优异的正预测值 (≥0.96) 和可比的诊断准确性.
结论:
- 治疗后早期的MRI反应评估可靠地预测了放射细分切除术治疗的HCC患者的长期结果.
- mRECIST,LI-RADS TRA和图像减法在预测响应方面表现相似.
- 这些发现支持使用早期MRI来评估该患者队列的治疗反应.
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