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周周甲状素与周周三氨基醇注射用于活性甲状腺相关的轨道病变:一种随机临床试验
Islam Y Swaify1, Haytham E Nasr2, Rania A El Essawy2
1Ophthalmology Department, Faculty of Medicine, Cairo University, Al-Saray Street, El-Manial, Cairo, Egypt. islamswaify@medicine.cu.edu.eg.
Japanese journal of ophthalmology
|August 4, 2023
概括
周周注射的甲状腺甲和氨可有效地管理与甲状腺相关的轨道病变,减少临床活性和亡. 这两种治疗都是安全的,甲索特雷克萨特显着降低了眼内压力.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺相关轨道病 (TAO) 是一种影响眼的自身免疫性疾病.
- 活跃的TAO需要有效和安全的治疗选择来管理像亡和炎症这样的症状.
研究的目的:
- 为了比较 periocular methotrexate 与 triamcinolone 注射的有效性和安全性,用于活性TAO.
- 评估治疗结果,包括临床活性,亡和眼内压力.
主要方法:
- 进行了一项前性,双面罩,随机的临床试验.
- 患者在一只眼睛中接受了三次周期性注射甲甲酸盐 (7.5毫克),在另一只眼睛中接受了三次周期性注射.
- 评估了临床活动评分,proptosis,眼开口,软组织征兆和眼内压力.
主要成果:
- 甲铁和氨都显著降低了临床活性评分和.
- 在这两种治疗中,人们观察到眼口径和软组织征兆的显著改善.
- 甲索酸导致眼内压力显著降低,与三氨不同.
- 在6个月后,两种治疗方法之间没有发现有效性或响应率的显著差异.
结论:
- 周周甲醇是一种有效和安全的替代品,用于管理活跃的TAO.
- 虽然通常是安全的,但应该考虑潜在的晚期并发症,如轨道脂肪缩.
- 在研究期间,这两种治疗方法都表现出良好的安全性概况,副作用最小.
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