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抗抑郁药和乳腺癌之间的关系:来自孟德尔随机化的证据
Dong Niu1,2, Chenchen Li1,2, Xiaoyu Yan1,2
1Henan University of Chinese Medicine, Zhengzhou, China.
Cancer causes & control : CCC
|August 4, 2023
概括
这项研究发现抗抑郁药或SSRI使用与乳腺癌风险之间没有联系. 然而,高血清素水平与乳腺癌风险增加存在因果关系,特别是ER阳性类型.
科学领域:
- 药物基因组学 药物基因组学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 抗抑郁药的使用量有所增加,但由于混因素,其与乳腺癌风险的关联尚不清楚.
- 以前的研究已经产生了不一致的发现,关于抗抑郁药的使用和乳腺癌之间的联系.
- 门德尔的随机化 (MR) 方法对于调查因果关系而最大限度地减少混是有价值的.
研究的目的:
- 评估使用抗抑郁药,特别是SSRI药物对乳腺癌风险的因果关系.
- 研究血清激素和益生菌水平在SSRI使用和乳腺癌之间的关系中的潜在作用.
- 测试SSRI药物会增加益生菌度,从而影响乳腺癌风险的假设.
主要方法:
- 采用双样本的门德尔随机化 (MR) 方法,将全基因组关联研究数据聚合起来.
- 选择的单核酸多态 (SNPs) 与抗抑郁药,SSRI药物,血清素和益生菌素作为仪器变量有很强的相关性.
- 采用逆方差加权 (IVW),MR-Egger回归和加权中位数方法进行可靠的关联分析.
主要成果:
- 抗抑郁药或SSRI使用与乳腺癌风险 (整体,ER阳性或ER阴性) 之间没有发现显著的关联.
- 血清激素度没有显示出与乳腺癌风险的显著关联.
- 观察到高血清素水平与乳腺癌风险增加,特别是ER阳性乳腺癌之间存在积极的因果关系.
结论:
- 大规模的门德尔随机化分析表明,抗抑郁药和SSRI药物与乳腺癌风险无关.
- 建议的途径涉及SSRI药物,高血清素和随后的乳腺癌风险没有得到研究结果的支持.
- 升高的益乳素水平代表了乳腺癌的潜在因果因素,独立于SSRI药物使用.
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