FBXO24 通过准 LSD1 的 Ubiquitination 来抑制乳腺癌瘤发生
Bo Dong1,2, Xiang Song1,2,3,4, Xinzhao Wang1,2
1Department of Pharmacology & Nutritional Sciences, University of Kentucky School of Medicine, Lexington, Kentucky.
Molecular cancer research : MCR
|August 4, 2023
概括
FBXO24针对素特异性脱甲酶1 (LSD1) 的瘤基因进行降解,抑制乳腺瘤的进展. 这一发现确定FBXO24是一种瘤抑制剂,为乳腺癌提供了新的治疗策略.
科学领域:
- 表观遗传学和癌症生物学
- 瘤发生的分子机制
- 瘤抑制器功能 瘤抑制器功能
背景情况:
- 氨酸特异性去甲基酶1 (LSD1) 是一种染色质修饰剂,在各种癌症中起着瘤基因的作用.
- 虽然LSD1的稳定性由无化和二化调节,但其降解途径尚不清楚.
- 了解LSD1降解对于制定减轻其致癌功能的策略至关重要.
研究的目的:
- 为了确定负责LSD1降解的E3酶.
- 阐明FBXO24在调节LSD1稳定性和功能的作用.
- 调查FBXO24作为乳腺癌瘤抑制剂的潜力.
主要方法:
- 对人类SCF家族E3酶进行无偏见的siRNA查.
- 乌比基化试验证实了FBXO24对LSD1.1.的结合酶活性.
- 在乳腺癌患者样本中分析FBXO24和LSD1表达.
主要成果:
- 鉴定FBXO24为E3结合酶,该结合酶在LSD1.1中无处不在并降解LSD1.
- FBXO24抑制LSD1诱导的瘤发生,并在乳腺癌细胞中起到瘤抑制作用.
- FBXO24表达与LSD1水平相反相关,并预测乳腺癌患者的预后良好.
结论:
- FBXO24针对LSD1进行降解,从而抑制乳腺瘤的进展.
- 通过控制LSD1稳定性,FBXO24作为关键瘤抑制剂起作用.
- 准FBXO24-LSD1轴为乳腺癌提供了一个潜在的治疗策略.
更多相关视频
07:48Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
11.4K
07:16Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
19.8K
相关概念视频
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:12Loss of Tumor Suppressor Gene Functions
4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K