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默克尔细胞癌中索马托斯塔丁受体表达:与临床数据的相关性

Klaus W Fagerstedt¹, Tiina Vesterinen², Helena Leijon²

¹Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Acta oncologica (Stockholm, Sweden)

|August 4, 2023

概括

索马托斯坦素受体 (SSTRs) 在默克尔细胞癌 (MCC) 中存在. SSTR2表达与转移性疾病相关,表明它有可能成为这种罕见的皮肤癌的预后标志物.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
分子生物学分子生物学

背景情况:

默克尔细胞癌 (MCC) 是一种罕见的,侵袭性的神经内分泌皮肤瘤.
体静止素受体 (SSTRs) 调节细胞生长,并在各种神经内分泌瘤中表达.
关于SSTR在MCC中的表达及其临床相关性的数据有限.

研究的目的:

为了研究默克尔细胞癌 (MCC) 中体静止素受体 (SSTR1-5) 的表达.
确定SSTR表达和临床参数之间的关联,包括患者的结果.

主要方法:

在组织微阵列上使用免疫组织化学对99个MCC组织样本进行回顾性分析.
对SSTR1-5表达的研究.
SSTR表达与临床数据和患者结果的相关性.

主要成果:

在69%,6%,4%和1%的MCC瘤中分别检测到索马托斯坦素受体SSTR2,SSTR3,SSTR4和SSTR5.
没有观察到SSTR1表达.
细胞质SSTR2阳性与诊断时的转移性疾病有显著的关联 (p=0.009),但与整体存活率没有关联.

结论:

索马托斯塔丁受体,特别是SSTR2,在默克尔细胞癌中表达.
在诊断时,SSTR2表达是与转移性疾病相关的临床相关标志物.
SSTR2可以作为预后标志物,并为MCC提供成像和体静止素类似疗法的目标.

关键词:

梅克尔细胞癌瘤是什么?免疫组织化学免疫组织化学索马托斯坦因子受体是什么

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