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Updated: Jul 20, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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一个新的"激活开关"动机,所有氨基酶受体都有共同的动机

Kuo Hao Lee1, Jamie J Manning2,3,4, Jonathan Javitch2,3,4

  • 1Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse─Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States.

Journal of chemical information and modeling
|August 4, 2023
PubMed
概括

氨基酶受体经历激活形状变化 (ACCs),独立于连接体结构. 一个新的"激活开关"图案涉及跨膜螺旋体3,5和6,整合了受体信号的关键元素.

关键词:
氨基酶受体是一种氨基酶受体.合规性分析是一种分析.化-EM结构的结构.晶体结构的结晶结构.带结合口袋的口袋.受体激活受体的激活方式

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