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一种酸 - 基托桑复杂的双功能涂层,用于改善基生殖的分化和子植入物的杀菌性质
Tong Wu1, Qiyue Zhou1, Gaoying Hong1
1Department of Prosthodontics, Affiliated Stomatology Hospital of Nanjing Medical University; Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing 210029, China.
Colloids and surfaces. B, Biointerfaces
|August 4, 2023
概括
对于齐尔科尼亚牙植入物的新表面涂层促进骨生长,并与细菌作斗争. 这种聚乙烯 (imine) /氨酸/花酸-酸涂层增强骨质生成,并抑制有害细菌而不损害细胞.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 表面化学 表面化学
背景情况:
- 齐尔科尼亚牙植入物因细菌殖民而面临着 osteogenesis 和 peri-implantitis 缺陷的挑战.
- 开发促进骨生长和具有抗菌性能的表面处理对于稳定四角 (Y-TZP) 植入物至关重要.
研究的目的:
- 开发用于Y-TZP植入物的功能表面修饰,使用聚乙烯胺/氨酸/酸-酸 (PEI/HA/CGA-CS) 结合物.
- 为了增强质分化和土表面的抗菌活性.
主要方法:
- 一个PEI/HA/CGA-CS结合物的层次沉积 (LBL) 在表面上.
- 评估表面湿透性,酸 (CGA) 释放,细胞粘附,增殖,分化和化.
- 对 Porphyromonas gingivalis 和Aggregatibacter actinomycetemcomitans 的抗菌活性进行评估.
- 研究对骨质细胞生物活动和Wnt/β-catenin信号通路的影响.
主要成果:
- PEI/HA/CGA-CS涂层提高了石表面的湿透性,并确保了稳定的CGA释放.
- 这种涂层促进了骨质母细胞的早期细胞粘附,增殖,分化和化.
- 观察到有效抑制P. gingivalis和A. actinomycetemcomitans的增殖和活性,而不会损害骨质细胞活力.
- 在MC3T3-E1细胞中增强的骨质生成与增加的尼弗罗内克丁 (NPNT) 表达和Wnt/β-catenin通路激活有关.
结论:
- PEI/HA/CGA-CS功能涂层为改善土牙植入物性能提供了一个有前途的策略.
- 这种表面修饰增强了骨质生成潜力和抗菌疗效,解决了当前石植入物的关键局限性.
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