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改善了含有Eulophia macrobulbon提取物的转移体的皮肤透

Sasawat Potisuwan¹, Nutsawadee Apichatwatana¹, Soravoot Rujivipat²

¹Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Colloids and surfaces. B, Biointerfaces

|August 4, 2023

概括

欧洛菲亚麦克罗布尔本 (EM) 提取物载荷转基因组增强生物活性化合物的皮肤透. 转移体和EM溶液的新组合进一步改善了输送,为透皮应用提供了潜力.

科学领域:

药理学药理学是指药理学的学科.
材料科学材料科学材料科学
皮肤病学皮肤病学

背景情况:

转基因组为生物活性化合物提供了增强的皮肤透.
欧洛菲亚麦克罗布尔本 (EM) 提取物含有有价值的生物活性化合物.
优化自然化合物通过皮肤传递至关重要.

研究的目的:

为了表征EM提取载荷转移体.
为了评估EM提取物配方的皮肤透.
开发和评估一个结合的转基因和溶液系统,以改善通过皮肤递送.

主要方法:

配制带有EM提取物的转基因组,含有不同度的酸丁胆和表面活性剂.
转移体的特征:形态学,捕获效率 (EE),囊泡大小,多分散性指数 (PDI) 和泽塔潜力.
使用Strat-M®合成膜评估皮肤透率并测量滞后时间.

主要成果:

囊泡大小与酸胆过渡温度 (Tm) 和表面活性剂水友性-脂友性平衡 (HLB) 相相关.
在各种配方中,EE,PDI和zeta潜力保持一致.
与EM溶液相比,EM转基因组显示出更高的膜透性,而EM溶液的滞后时间更短.
结合EM转移体和EM溶液的配方减少了滞后时间和增加了膜透率.

结论:

带有EM提取物的转基因组有效地增强了皮肤透.
一个新的EM转移体和EM溶液的综合系统显著改善了通过皮肤传递.
这种方法显示出作为天然生物活性化合物的高效透皮药物递送系统的前景.

关键词:

可以变形的可变形性.边缘激活器激活器欧洛菲亚巨型球球通过皮肤透.转基因组是转基因组中的一个.转移体-溶液组合的组合.

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