超重的孙子和祖父的饥饿暴露
1University of California, Los Angeles, United States of America; National Bureau of Economic Research, United States of America.
Journal of health economics
|August 4, 2023
概括
祖父的祖父们的祖父们
科学领域:
- 表观遗传学和跨世代健康
- 营养流行病学 营养流行病学
- 人类进化生物学 人类进化生物学
背景情况:
- 全球超重和肥胖率的上升,特别是在发展中国家.
- 历史上的饥荒和营养不良影响后代的健康.
- 对于父母在发育过程中的饥饿对代际影响的理解有限.
研究的目的:
- 为了调查父亲祖父的发育性饥饿暴露和孙子的超重状态之间的联系.
- 探索潜在的代谢健康的跨世代表观遗传.
- 为了检查男性血统后裔的长期死亡风险.
主要方法:
- 研究了联邦陆军内战士兵的孙子,比较了那些祖父是战俘 (饥饿) 和非战俘的人.
- 在成年孙子中分析了超重的患病率和体重指数 (BMI).
- 在45岁以后的男性直系孙子中评估了全因死亡风险.
主要成果:
- 曾经经经历过严重囚禁 (饥饿) 的祖父的男性孙子,平均超重增加了21%,平均BMI增加了2%.
- 在女性直系孙子身上没有观察到显著的影响.
- 饥饿祖父的男性孙子在45岁后年均死亡风险高22% - 28%,超重对这种过度风险的贡献为9% - 14%.
结论:
- 父亲祖父在发育期间的饥饿可能会增加孙子的超重风险和死亡率,这表明跨代的影响.
- 证据支持男性系遗传在代谢健康结果中的作用跨世代.
- 研究结果强调了早期营养压力对后代健康的持久影响.
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