通常间歇性肺炎的放射分级系统与死亡率相关,可以作为临床试验中的替代终点
Kathleen M Capaccione1, Mary M Salvatore1
1Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, United States of America.
常见间歇性肺炎 (UIP) 和异常性肺纤维化 (IPF) 的新分级系统显示,与患者死亡率有显著的相关性. 这种经过验证的系统可以帮助监测疾病进展,并在临床试验中作为替代终点.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 常见间歇性肺炎 (UIP),也称为异常性肺纤维化 (IPF),是一种进展性肺病,预后不佳.
- 一个以前建立的UIP放射学分级系统已经与肺功能测试显示了相关性.
研究的目的:
- 测试该假设,即UIP/IPF已建立的放射学分级系统与患者死亡率相关.
- 验证这种分级系统在临床实践和抗纤维菌剂试验中监测疾病进展的有用性.
主要方法:
- 对放射学记录系统的审查确定了94名符合UIP/IPF纳入标准的患者.
- 胸部CT扫描通过两个心胸放射科医生的共识进行了分级.
- 使用斯皮尔曼相关性分析,将CT等级与成像和死亡之间的间隔相关联.
主要成果:
- 在CT等级和死亡率之间发现了显著的正相关性 (rs = 0.37732,p = 0.00018).
- 亚组分析显示,成像和死亡之间的间隔≤100天 (rs = 0.48339,p = 0.03602) 和>100天 (rs = 0.302,p = 0.00846) 的患者中存在正相关性.
结论:
- 这些数据支持UIP/IPF的放射学分级系统,用于监测临床进展.
- 该系统可以在抗纤维菌剂的临床试验中作为替代终点.
- 未来的研究将专注于其在临床试验中的实用性和自动分级的发展.
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