妊娠糖尿病和孕产妇肥胖症中的胎盘内皮功能障碍:对编程心血管疾病的潜在威胁
Mariana S Diniz1, Ursula Hiden2, Inês Falcão-Pires3
1CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Ph.D. Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.
孕期糖尿病 (GDM) 和孕产妇肥胖 (MO) 可以导致胎盘内皮功能障碍,增加后代心血管疾病的风险. 研究强调氧化和L-氨酸路径是关键目标.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 发展生物学 发展生物学
背景情况:
- 孕期糖尿病 (GDM) 和孕产妇肥胖 (MO) 与胎儿不良结果和晚年心血管疾病有关.
- 这些条件可能会通过涉及胎盘单元的机制为后代编程疾病.
- 胎盘内皮功能障碍是这个编程的一个关键因素.
研究的目的:
- 审查胎盘内皮功能障碍在GDM和MO怀孕中的后代心血管疾病风险中的作用.
- 检查母亲健康状况对胎盘血管功能和胎儿发育的影响.
- 确定涉及胎盘血管功能障碍的关键分子通路.
主要方法:
- 文献综述侧重于GDM,MO和胎盘内皮功能障碍.
- 对研究血管发育和受影响怀孕中信号通路的研究进行分析.
- 综合有关氧化和硫化作用的当前知识.
主要成果:
- 母亲的健康状况有助于胎盘内皮功能障碍,损害胎儿的心血管发育.
- 氧化和硫化涉及到调解胎盘血管功能障碍.
- 确定L-氨酸-氧化物和氨酸-L-氨酸-氧化物 (ALANO) 途径是关键目标.
结论:
- 胎盘内皮功能障碍是将母亲GDM/MO与后代心血管疾病联系起来的重要机制.
- 准L-氨酸-氧化信号通路可能提供治疗策略.
- 需要进一步的研究,以解决现有的知识差距在这个领域.
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