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长非编码RNA调解了短期PM_2.5暴露与系统性炎症循环生物标志物之间的关联

Qinqin Diao¹, Xiaodi Qin¹, Ningdong Hu²

¹The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, China; Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, 511436, China.

Environmental pollution (Barking, Essex : 1987)

|August 4, 2023

概括

短期接触细颗粒物 (PM2.5) 引发系统性炎症,而血长非编码RNAs (lncRNAs) 调解这些影响. 这些发现表明,lncRNAs可以作为PM2.5健康风险的生物标志物.

科学领域:

环境健康环境健康
分子生物学分子生物学
生物标志物生物标志物

背景情况:

短期暴露于细颗粒物 (PM2.5) 与全身炎症有关.
长非编码RNAs (lncRNAs) 在调解PM2.5的炎症作用中的作用尚不清楚.

研究的目的:

调查血lncRNA是否调解了短期PM2.5暴露与全身炎症之间的关联.
为了确定参与这种调解途径的特定 lncRNA.

主要方法:

对161名成年人进行的横截面研究,测量了血生物标志物 (CC16,IL-6,IL-8,TNF-α) 和lncRNA表达.
估计PM2.5度使用0-3天移动平均值.
用多个线性回归和调解分析来评估关联和调解效应.

主要成果:

暴露于PM2.5与增加IL-6,TNF-α,IL-8和CC16水平有关.
在PM2.5和四种新型lncRNA之间观察到负相关性 (lnc-ACAD11-1:1, lnc-PRICKLE1-4:1, lnc-GPR39-7:2, lnc-MTRNR2L12-3:6).
这些lncRNAs显著调节了PM2.5对测量的炎症生物标志物的影响,调节比例从2.27%到35.60%不等.

结论:

血lncRNA表达调解了PM2.5暴露对全身炎症的急性影响.
循环中的lncRNAs可以作为评估和减轻与PM2.5暴露相关的健康风险的有价值的生物标志物.

关键词:

CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 CC16 微细颗粒物质的细颗粒物质的细颗粒物质在IL-6的研究中,IL-6被认为是IL-6的基因.它们的IL-8和IL-8是不同的.这是一个LncRNARNA.这就是TNF-α.

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