在22q11.2删除综合征中,氧化应激和精神障碍之间的关系
Noam Matalon1, Elfi Vergaelen2, Shachar Shani3
1Behavioral Neurogenetics Center, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel; Pediatric Molecular Psychiatry Laboratory, Sheba Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Brain, behavior, and immunity
|August 4, 2023
概括
患有22q11.2删除综合征 (22q11.2DS) 的个体表现出更高的基线氧化应激 (OS) 和细胞弹性降低. 患有精神病的人对OS更敏感,这表明它在22q11.2DS表型中的作用.
科学领域:
- 遗传学和分子生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 22q11.2删除综合征 (22q11.2DS) 是一种常见的微删除,与免疫和神经精神疾病有关.
- 大约30%的22q11.2DS患者会患上精神病,包括精神分裂症.
- 神经炎症和氧化应激 (OS) 与精神分裂症病理生理学有关.
研究的目的:
- 研究22q11.2DS,OS和精神分裂症之间的相互作用.
- 评估22q11.2DS,有或没有精神疾病的个体的OS水平和细胞弹性.
主要方法:
- 在两个国际站点收集了125名参与者的血液样本 (73名22q11.2DS,52名健康对照).
- 使用髓氧化酶 (MPO) 活性测量了基线OS.
- 在亚样本中的诱导OS下评估了外周血液单核细胞 (PBMC) 存活率.
主要成果:
- 与健康对照组相比,22q11.2DS患者的MPO水平显著更高 (p=.004).
- 来自22q11.2DS个体的PBMC对诱导的OS的抵抗力较低.
- 22q11.2DS 患有精神疾病的个体对诱导的OS表现出更高的敏感性 (p=.003).
结论:
- 操作系统调节失调可能会导致22q11.2DS表型,特别是在患有精神病的人群中.
- 虽然精神病亚组的基线OS没有显著不同,但他们的细胞更容易受到诱导的OS的影响.
- 调查结果可能有助于早期识别风险标志物,并制定针对22q11.2DS和相关精神病障碍的有针对性的干预措施.
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