3D打印结合生物预测溶解和PBPK/PD建模优化和药物治疗个性化:我们到达了吗?
Gabriela Wyszogrodzka-Gaweł1, Olha Shuklinova2, Bartek Lisowski2
1Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Drug discovery today
|August 4, 2023
概括
基于模型的精确剂量 (MIPD) 通过使用预测模型和患者数据来优化药物治疗. 这个工作流整合了基于生理学的药理动力学/药理动力学 (PBPK/PD) 模型与3D打印药物进行个性化治疗.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
背景情况:
- 精准医学需要量身定制的药物剂量,以获得最佳的患者结果.
- 基于模型的精确剂量 (MIPD) 利用预测建模来平衡治疗的好处和风险.
- 个体患者的特征,疾病状态和治疗方式都会影响药物的疗效和安全性.
研究的目的:
- 概述一个理论工作流程来实现模型信息精确剂量 (MIPD).
- 将基于生理学的药理动力学/药理动力学 (PBPK/PD) 模型整合到精确剂量框架中.
- 探索3D打印药物的应用,以提供精确建模的剂量.
主要方法:
- 开发一个理论工作流程,将PBPK/PD模型连接到患者特定的剂量.
- 在MIPD工作流程中整合信息流和数据管理.
- 考虑3D打印平板作为剂量定制的平台.
主要成果:
- 拟议的工作流建立了一个针对个性化药物治疗方案优化框架.
- 基于生理学的药理动力学/药理动力学 (PBPK/PD) 模型对于预测个体患者的反应至关重要.
- 3D打印平板电脑提供了一种潜在的方法,可以提供精确的,基于模型的剂量.
结论:
- 基于模型的精确剂量 (MIPD) 是一种有希望的方法来提高治疗结果.
- 整合PBPK/PD建模和先进的药物输送系统,如3D打印平板电脑是关键.
- 解决数据集成,建模和实施方面的挑战对于临床翻译至关重要.
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