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肝移植对宿主疾病:我们知道什么,何时做活检,如何诊断?

Ashley E Stueck¹, M Isabel Fiel²

¹Department of Pathology, Dalhousie University, 715 - 5788 University Avenue, Halifax, NS, B3H 2Y9, Canada.

Human pathology

|August 4, 2023

概括

移植与宿主疾病 (GVHD) 是血液细胞移植 (HCT) 后的一种严重并发症. 组织病理学有助于诊断肝脏GVHD (hGVHD),指导关键病人的管理.

科学领域:

移植免疫学移植免疫学
胃肠病学和肝病学
血液学血液学血液学

背景情况:

移植与宿主疾病 (GVHD) 是血液细胞移植 (HCT) 后的一种严重并发症.
肝性GVHD (hGVHD) 存在诊断挑战,原因是HCT患者的症状与其他肝脏疾病重叠,例如鼻状阻塞综合征和药物诱导性肝损伤 (DILI).
准确的hGVHD诊断对于及时有效的患者管理至关重要.

研究的目的:

突出诊断挑战在肝脏GVHD (hGVHD) 和肝脏功能障碍的其他原因在血液细胞移植 (HCT) 接受者区分肝脏GVHD.
强调肝活检和组织病理学在诊断hGVHD中的作用.
讨论临床表现,组织病理特征和hGVHD的管理.

主要方法:

肝脏GVHD (hGVHD) 的组织病理特征的审查.
对临床和实验室发现的分析,以区分hGVHD与其他肝脏疾病.
讨论急性GVHD目前的治疗策略,包括类固醇治疗和二线选择.

主要成果:

肝性GVHD (hGVHD) 呈现出一系列的组织病理变化,主要影响细胞间胆道.
关键的组织病理学发现包括核和细胞质异常,胆道亡和亡.
急性hGVHD可以呈现为严重的肝炎,而慢性hGVHD涉及渐进的胆道损失和纤维化.

结论:

肝脏活检和组织病理学检查对于在血液细胞移植 (HCT) 患者中诊断肝脏GVHD (hGVHD) 是非常宝贵的.
准确的hGVHD诊断对于启动适当的治疗和改善患者的结果至关重要.
GVHD,特别是hGVHD,与显著的发病率和死亡率有关,强调需要有效的诊断和治疗策略.

关键词:

在GVHD中,GVHD是指GVHD 血造细胞移植是血造细胞的移植.肝脏移植对宿主疾病肝脏移植对宿主疾病肝脏活检活检是什么意思肝脏功能障碍肝脏功能障碍肝脏病理肝脏病理 hGVHD高清高清视频在线观看在线观看

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