通过专门的全国性抗菌药物管理计划,减少手术患者抗生素治疗的持续时间. 一个前性,干预性队列研究
Maria Batlle1, Josep M Badia2, Sergi Hernández3
1Department of Surgery, Hospital General Granollers, Universitat Autònoma de Barcelona, Barcelona, Spain.
International journal of antimicrobial agents
|August 4, 2023
概括
这项研究表明,全国范围内的抗生素管理计划显著减少了手术患者抗生素治疗的持续时间. 对建议的高度遵守导致了更短的治疗疗程,改善了抗微生物药物管理.
科学领域:
- 传染性疾病 传染性疾病
- 手术感染 手术感染
- 抗微生物药物管理委员会
背景情况:
- 目前的指导方针建议在适当的源控制下为手术感染服用5-7天的抗生素.
- 在全国范围内实施了一项干预措施,将手术患者的抗生素治疗时间减少到不到7天.
研究的目的:
- 评估全国范围的抗生素管理干预措施在减少手术患者抗生素治疗时间方面的有效性.
- 分析是否遵守管理建议,并确定影响治疗持续时间的因素.
主要方法:
- 在32家医院进行了前性队列研究,评估了接受抗生素7天或更长时间的手术患者.
- 收集的数据包括治疗的指示,源控制的质量,发布的建议和遵守率.
- 使用线性回归和皮尔森相关系数分析了长时间抗生素治疗的时间趋势.
主要成果:
- 在32499名患者中,13.7%接受了持续7天或更长时间的治疗.
- 管理干预主要针对整体外科和泌尿病患者,腹部内感染是最常见的.
- 在研究期间观察到长期抗生素治疗的显著下降 (Pc=-0.69;P < 0.001),整体坚持率为91.5%.
结论:
- 管理计划成功地减少了手术部门的抗生素治疗时间.
- 严格遵守推,特别是一般手术和腹部内感染,有助于观察到的减少.
- 这些发现支持实施类似的管理计划,以优化手术环境中的抗生素使用.
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