孕期长度与纯种子的早期肢体形有关
Rebecca Mouncey1, Juan Carlos Arango-Sabogal2, Amanda M de Mestre3
1Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK.
Journal of equine veterinary science
|August 4, 2023
概括
马的曲和角肢体形 (LD) 是很常见的. 马的更长的怀孕期似乎可以降低纯种子早期肢体变形的风险.
科学领域:
- 马类兽医科学 马类兽医科学
- 生殖生物学 生殖生物学
- 遗传缺陷研究研究 遗传缺陷研究
背景情况:
- 柔性和角性四肢形 (LD) 是年轻纯种马患病和死亡的重要原因.
- 这些先天性疾病的确切原因仍然在很大程度上是未知的.
- 假设影响子宫内发育的孕产妇和怀孕因素发挥了作用.
研究的目的:
- 调查孕产妇和怀孕因素之间的关联,以及纯种子早期肢体变形的发生.
- 为了确定新生马的四肢形的潜在危险因素.
主要方法:
- 在七个英国和爱尔兰农场进行了前性出生队列研究.
- 关于马匹信号,繁殖史和怀孕细节的数据被追溯收集.
- 在头六个月内,对子四肢形的兽医干预被前性地记录.
- 使用多变量逻辑回归来评估马/怀孕因素和后代LD之间的关联.
主要成果:
- 分析了两个繁殖季节的275个怀孕记录.
- 21%的活小 (57/272) 在出生后六个月内需要兽医干预,以防LD.
- 在314天和381天之间的每一个额外的妊娠日 (OR 0.96,P = .01) 中,LD的几率下降了4%.
结论:
- 更长的怀孕时间,即使在正常范围内,也与纯血动物小子早期肢体变形的几率降低有关.
- 孕期长度是影响四肢形发展的重要因素.
- 需要进一步的研究,以了解连接妊娠时间和四肢发育的潜在生物机制.
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