性别,种族,体重指数和与NSAID加剧的呼吸道疾病相关的环境暴露 症状序列
Kelley Nicole Dages1, Olufemi Sofola-James2, Esha Sehanobish3
1Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn.
The journal of allergy and clinical immunology. In practice
|August 4, 2023
概括
非类固醇抗炎药物 (NSAID) 加剧的呼吸道疾病 (N-ERD) 的进展有显著的变化. 性,BMI,种族,种族和环境等因素影响N-ERD患者的疾病模式和诊断延迟.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
背景情况:
- 非类固醇抗炎药物 (NSAID) 加剧的呼吸道疾病 (N-ERD) 呈现出三重症状:鼻多重症,喘和NSAID过敏.
- 在N-ERD中,症状发作和疾病进展的确切时间尚不清楚.
研究的目的:
- 为了描述N-ERD的疾病进展.
- 确定与不同N-ERD发病模式和诊断延迟相关的因素.
主要方法:
- 与240名N-ERD患者进行了前性访谈.
- 根据患者最初出现的症状 (喘,鼻,NSAID过敏或同时发病) 将患者分为四组.
- 统计分析检查了患者特征与这些组之间的关联,以及"喘第一"子组内的关联.
主要成果:
- 喘作为第一个症状与更年轻的发病年龄和更高的BMI有关.
- 作为第一个症状的NSAID敏感性与男性性别和污染暴露有关.
- 观察到3年的显著诊断延迟,黑人和拉丁裔患者的低诊断更为普遍.
结论:
- N-ERD在发病和进展方面表现出相当大的变化.
- 患者的性别,BMI,种族/民族和环境暴露与N-ERD疾病模式有显著的关联.
- 这些因素也影响了诊断N-ERD的延迟.
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