设计,合成,抗微生物活性和分子对接研究的化 bis-化-银(I) 复合体
Elvan Üstün1, Neslihan Şahin2, İlknur Özdemir3,4
1Department of Chemistry, Faculty of Art and Science, Ordu University, Ordu, Türkiye.
Archiv der Pharmazie
|August 4, 2023
概括
新的银 (((I) 复合物显示出强大的抗真菌活性,其最小的抑制度是对真菌的flukonazole的两倍. 这些化合物还对各种细菌表现出适度的抗微生物作用.
科学领域:
- 协调化学 协调化学
- 药用化学 医学化学
- 计算化学计算化学
背景情况:
- 银复合物与N-异环被探索为生物活动.
- 西米达衍生物以其多样化的药理特性而闻名.
- 银 ((I) 协调化合物具有潜在的抗微生物和抗真菌应用.
研究的目的:
- 为了合成和表征新的酸复合物.
- 评估这些合成复合物的抗微生物和抗真菌疗效.
- 用计算方法研究这些复杂物与目标酶的分子相互作用.
主要方法:
- 合成和完全描述八个N-协调的银 (I) 复合体.
- 查抗微生物活性对抗格拉姆阴性和格拉姆阳性细菌.
- 对Candida albicans和Candida glabrata进行抗真菌活性测试.
- 用大肠杆菌DNA旋转酶和Candida glabrata CYP51.1.进行分子对接研究.
- 使用密度函数理论 (DFT) 计算分子反应性描述器.
主要成果:
- 合成的银(I) 复合物对测试的细菌表现出中度的最小抑制度 (MIC).
- 观察到显著强大的抗真菌活性,MIC值为0.011μmol/mL对真菌,是弗卢可纳的两倍低.
- 分子对接揭示了与细菌和真菌向酶的潜在相互作用.
结论:
- 这种新型的bis ((胺醇) 银 ((I) 复合物表现出有前途的抗真菌特性,性能优于fluconazole.
- 这些复合物代表着一种潜在的新类抗真菌剂.
- 需要进一步研究它们的作用机制和治疗潜力.
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