第一次怀孕和随后的怀孕结果中的孕前症:全国性的队列研究
Eva Havers-Borgersen1,2, Emil Fosbøl3, Marianne Johansen4
1Department of Cardiology, Rigshospitalet, København, Denmark evaborgersen@gmail.com.
Journal of epidemiology and community health
|August 4, 2023
概括
在第一次怀孕中患有先兆子 (PE) 的女性,其后分娩率略低一些. 复发性前列腺炎的风险是六分之一,但在未来的怀孕中,母亲和新生儿的结果显著改善.
科学领域:
- 产科和妇科 产科和妇科
- 生殖医学 生殖医学
- 围产儿医学 围产儿医学
背景情况:
- 在第一次怀孕中,先兆子 (PE) 存在复发和随后分娩结果的风险.
- 了解这些风险对于患有PE的女性至关重要,特别是需要早产的严重病例.
研究的目的:
- 评估有或没有先兆子 (PE) 病史的妇女的后期分娩率.
- 检查PE的复发率以及随后怀孕中相关的孕产妇和新生儿结局.
主要方法:
- 一项观察性队列研究利用丹麦全国性的登记册来识别1997-2016年间的初婚妇女.
- 妇女根据PE发育而分层,并对随后的出生,移民,死亡或研究结束进行了跟踪.
- 使用阿伦-约翰森和考克斯回归模型分析了后续分娩的累积发病率和PE复发,孕产妇和新生儿发病率/死亡率等结果.
主要成果:
- 在510,615名女性中,4.2%的女性患有PE (0.4%的早期发病).
- 患有PE的女性的后期出生率较低 (57.4%),而对照组 (61.2%),早期发病的PE (49.4%) 显著较低.
- 复发性PE的比率为15.8% (早期发病的PE为31.5%),妊娠年龄有所改善,并在随后的怀孕中降低了母亲/新生儿发病率和死亡率.
结论:
- 患有PE的初生妇女的后期出生率略低.
- 虽然复发性PE的风险是6分之一,但随后的怀孕显示出明显改善的孕产妇和新生儿健康结果.
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