在状细胞疾病中,输血的全球负担
Baba Pd Inusa1, Wale Atoyebi2, Biree Andemariam3
1Guy's and Saint Thomas' NHS Foundation Trust, London, UK.
概括
状细胞疾病 (SCD) 的管理依赖于红细胞 (RBC) 输血,但获得和安全是主要的挑战,特别是在资源较少的环境中. 解决这些问题对于改善全球患者的治疗结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 状细胞病 (SCD) 是一种普遍存在的遗传性血液疾病,其特征是异常的红细胞 (RBC).
- SCD导致广泛的健康并发症,从幼年开始影响多个器官系统.
- 红细胞输血是管理SCD并发症的关键干预措施,但慢性输血治疗也带来了自己的挑战.
研究的目的:
- 审查SCD的全球影响.
- 检查SCD目前的治疗方式.
- 要突出与慢性红细胞输血在SCD患者相关的挑战.
主要方法:
- 文献综述侧重于SCD病理生理学,治疗方法和输血相关问题.
- 分析低收入和中等收入国家 (LMICs) 医疗保健获取差异.
- 检查LMIC的输血安全性和后勤挑战.
主要成果:
- 许多患者的SCD需要慢性红细胞输血,导致铁过载,合免疫和感染等并发症.
- 低低收入国家在获得基本的SCD护理方面面临重大障碍,包括新生儿查和预防性治疗.
- 无法获得安全的红细胞和血液采集,处理和匹配系统的缺陷严重影响LMIC中SCD患者的护理.
结论:
- 有效的SCD管理需要解决慢性红细胞输血的复杂性.
- 在获得医疗保健和输血基础设施方面的全球差异不成比例地影响着低至中产国家中SCD患者.
- 改善红细胞输血服务和整体医疗保健服务对于减少全球SCD发病率和死亡率至关重要.
更多相关视频
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.5K
08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
9.9K
相关概念视频
Blood Transfusion
613
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
613
Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
Bone Marrow Sampling and Transplants
360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
360
Multiple Allele Traits
34.3K
The Concept of Multiple Allelism
34.3K
Disorders of Erythrocytes
992
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
992
Rh Blood Group
1.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
