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Bryce C Thomas¹, Dilana E Staudt¹, Alicia M Douglas¹

¹Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine, and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.

Trends in cancer

|August 4, 2023

概括

扩散性中线结质瘤 (DMG) 是一种罕见的儿科脑癌,其存活率很低. 化学抗原受体 (CAR) T细胞疗法通过克服其免疫抑制性瘤免疫微环境,显示出治疗这种中枢神经系统瘤的前景.

科学领域:

儿科瘤学儿科瘤学
神经瘤学神经瘤学
免疫治疗是一种免疫疗法.

背景情况:

扩散性中线质瘤 (DMG) 是一种具有悲观预后的侵袭性儿科脑癌.
目前的手术和放射治疗等治疗方法由于瘤的位置和透性质,提供了有限的生存益处.
在DMG中,瘤免疫微环境 (TIME) 的特征是具有免疫抑制性髓状细胞和少数淋巴细胞的"冷".

研究的目的:

审查目前的化学抗原受体 (CAR) T细胞治疗扩散中线质瘤 (DMG) 的现状.
探索瘤免疫微环境 (TIME) 对DMG中CAR T细胞疗法的疗效的影响.
确定克服DMG的CAR T细胞治疗挑战的策略.

主要方法:

对DMG的CAR T细胞治疗的临床前和临床研究的文献综述.
对DMG瘤免疫微环境 (TIME) 免疫特征的分析.
讨论潜在的治疗策略,以增强在DMG的CAR T细胞功能.

主要成果:

卡尔-T细胞疗法是DMG的新兴治疗方式,显示出治疗中枢神经系统耐药瘤的潜力.
DMG中的免疫抑制性TIME对CAR T细胞疗法的有效性构成重大障碍.
目前正在研究特定的策略来调节TIME并改善CAR T细胞活动.

结论:

卡尔-T细胞疗法代表了治疗儿科扩散性中线质瘤 (DMG) 的有希望的途径.
了解和克服免疫抑制性瘤免疫微环境 (TIME) 对于DMG中成功的CAR T细胞治疗至关重要.
需要进一步的研究和临床试验,以优化对DMG患者的CAR T细胞治疗.

关键词:

中枢神经系统的瘤仿制性抗原受体T细胞治疗T细胞治疗扩散的中线质瘤地方区域输液注入.瘤免疫的微环境

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