减少来自囊性纤维化患者的唾液样本的不必要测试:微生物学中的病理管理
Grace Butel-Simoes1, Despina Kotsanas2, Richard Streitberg3
1Department of Microbiology, Monash Pathology, Monash Health, Clayton, Vic, Australia; Monash Infectious Diseases, Monash Health, Clayton, Vic, Australia.
Pathology
|August 4, 2023
概括
在囊性纤维化 (CF) 患者中停止常规的Pseudomonas aeruginosa敏感性测试,显著降低了测试率. 这一变化并没有对住院人数,住院时间或死亡率产生负面影响,这表明潜在的资源节约.
科学领域:
- 医学微生物学 医学微生物学
- 临床诊断 临床诊断 临床诊断
- 传染性疾病 传染性疾病
背景情况:
- 慢性 Pseudomonas aeruginosa 感染在囊性纤维化 (CF) 肺部疾病中很常见,通常需要抑制性抗生素治疗.
- 肺非结核菌 (NTM) 感染在CF患者中也在增加,使诊断和治疗复杂化.
- 对多个分离物的常规敏感性测试是耗时的,其临床价值是不确定的.
研究的目的:
- 评估停止在CF患者中针对Pseudomonas aeruginosa分离物的常规敏感性测试的影响.
- 评估改变酸快菌根培养频率对实验室过程的影响.
- 确定与这些变化及其临床影响相关的成本和资源节约.
主要方法:
- 从2019年8月到2020年12月,实验室过程发生了变化,如果之前存在测试,则停止对P. aeruginosa进行例行敏感性测试.
- 如果在前6个月内进行常规培养酸敏细菌,则也会停止.
- 监测了临床结果,包括住院,住院时间和死亡率.
主要成果:
- 接受敏感性测试的P. aeruginosa分离物的比例从97%降至11%.
- 没有观察到有关住院,住院时间或死亡率的显著不良临床影响.
- 由于改进了实验室程序,记录了成本和资源的节省.
结论:
- 停止在CF患者中进行P. aeruginosa常规敏感性测试是一种可行的实验室过程变化.
- 这种测试策略的改变可以节省大量的成本和资源,而不会对患者的临床结果产生负面影响.
- 需要进一步评估,以确认长期益处,并完善CF中呼吸道病原体的诊断策略.
关键词:
囊性纤维化症是什么伪omonas aeruginosa易感性测试试验 伪omonas aeruginosa易感性测试试验 伪omonas aeruginosa易感性测试试验 伪omonas aeruginosa易感性测试试验实验室管理管理工作.菌根菌培养菌的培养更多相关视频
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