在接受血造干细胞移植条件化方案的血液性恶性瘤患者的抗性预防:系统性审查的研究方案
Nerea Baéz-Gutierrez1, Paloma Suárez-Casillas2, Maria Antonia Pérez-Moreno2
1Pharmacy Department, University Hospital Puerta del Mar, Cadiz, Spain.
概括
这一系统性审查综合了对干细胞移植患者化疗诱导的恶心和吐的抗性预防的证据. 目标是建立最佳的抗治疗方案,以改善患者的生活质量.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的恶心和吐 (CINV) 对接受血造干细胞移植 (HSCT) 的患者来说是一个重大挑战.
- 现有的指导方针缺乏针对HSCT中个别化疗方案量身定制的抗性预防的具体建议.
- 改善抗策略对于改善血液性恶性瘤患者的生活质量至关重要.
研究的目的:
- 系统地审查和综合有关血液恶性瘤的HSCT患者的抗emetic预防方案的证据.
- 为了确定在这个患者群体中进行抗性预防的最佳护理标准.
- 通过解决CINV. 来提高接受HSCT的患者的生活质量.
主要方法:
- 将使用主要数据库进行系统审查:MEDLINE (PubMed),EMBASE,临床试验.gov和Cochrane.gov.
- 将包括以英语,法语,意大利语或西班牙语出版的研究.
- 数据提取和偏差风险评估将由两名独立审查员执行,遵守PRISMA-P指南.
主要成果:
- 数据的综合和分析正在等待系统审查过程的完成.
- 对符合条件的研究进行偏差风险评估.
- 审查协议已注册在PROSPERO (CRD42023406380) 公司.
结论:
- 这些发现将有助于制定基于证据的建议,用于HSCT中抗性预防.
- 预计将为CINV管理建立最佳的护理标准.
- 这项研究旨在显著改善HSCT期间患者的治疗结果和生活质量.
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