大麻二醇对药物代谢的影响
Claudia Stöllberger1, Josef Finsterer2
1Office Wehlistraße, Anton Sattlergasse 4/22, Vienna A-1220, Austria.
European journal of internal medicine
|August 4, 2023
概括
大麻 (CBD) 可以抑制药物代谢蛋白质,可能导致有害的药物相互作用. 进一步的研究和医生意识对于CBD使用的患者安全至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物新陈代谢 药物新陈代谢
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻二醇 (CBD) 是广泛可获得的.
- 众所周知,CBD可以抑制许多药物代谢蛋白质 (DMP),包括P450酶 (CYP) 酶,碳素化酶1 (CES1),尿素5'-二酸-葡萄糖酶转移酶 (UGT) 酶,P-糖蛋白 (P-gp) 和乳腺癌抵抗蛋白 (BCRP).
- 这些潜在的CBD药物相互作用的临床意义在很大程度上仍未被描述.
研究的目的:
- 识别那些是DMP的基质,可能与口服CBD相互作用的药物.
- 为了确定CBD与药物相互作用是否已在科学文献中记录.
- 评估DMP基质在经常处方药物中的流行率.
主要方法:
- 系统识别403种药物作为DMP的基质.
- 文献审查以发现报告的CBD与药物相互作用 (人体,体内,体外).
- 在德国和美国最常被处方的药物中分析DMP基质频率.
主要成果:
- 在403个已识别的DMP基质中,有53个报告了CBD与药物相互作用.
- 在大多数报告的病例中 (31/53),CBD增加了基质水平;一个病例显示下降,四个没有变化.
- 对5/53基质观察到有争议的结果,对12/53基质没有报告的水平.
- 很大一部分经常被处方的药物 (67%在德国,68%在美国) 是DMP的基质.
结论:
- 迫切需要对CBD与药物相互作用进行全面的药理学研究.
- 对潜在风险的患者教育和提高医生意识是必不可少的.
- 监管机构应该在国际上解决这个问题,以提高CBD的安全性.
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