探索益生菌效应分子及其在肠-免疫相互作用中的作用模式
Choong-Gu Lee1,2,3, Kwang Hyun Cha1,2,3, Gi-Cheon Kim4
1Natural Product Informatics Research Center, Korea Institute of Science and Technology, 679, Saimdang-ro, Gangneung 25451, Korea.
FEMS microbiology reviews
|August 4, 2023
概括
益生菌通过调节肠道微生物群和免疫系统来提供健康益处. 本综述详细介绍了益生菌效应分子,例如来自Lactobacillus和Bifidobacterium的分子,以澄清它们的免疫调节机制.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 益生菌,即活微生物,通过改善肠道屏障功能,抑制病原体和调节免疫反应,显示出潜在的健康益处.
- 益生菌使用的临床结果各不相同,可能是由于不同的菌株,不一致的剂量和复杂的生物活性相互作用.
- 益生菌效应分子,特别是细菌细胞壁的组成部分,是宿主-益生菌相互作用和免疫信号的关键媒介.
研究的目的:
- 提供益生菌效应分子的全面概述,重点关注它们的结构和免疫特征.
- 阐明益生菌成分调节宿主免疫活动的分子机制.
- 确定当前的研究缺口,并提出了解益生菌介导免疫调节的未来方向.
主要方法:
- 文献综述综合了关于益生菌效应分子的现有研究.
- 专注于来自Lactobacillus和Bifidobacterium物种的效应分子.
- 分析益生菌成分与宿主受体之间的分子相互作用.
主要成果:
- 来自细菌细胞壁的益生菌效应分子,激活宿主信号通路.
- 这些分子对于调解益生菌对免疫平衡的有益作用至关重要.
- 这些分子的特定结构和免疫特征影响了它们的免疫调节潜力.
结论:
- 了解益生菌效应分子对于预测临床结果和优化益生菌疗法至关重要.
- 需要进一步的研究来充分描述这些分子及其在免疫调节中的精确作用.
- 针对性地研究乳杆菌和Bifidobacterium效应分子可以推动益生菌研究领域的进步.
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