声音触摸弹性图和量化的比较,以评估蛋白尿症患者的病变
Zhengmin Ruan1, Zhiying Xiao2, Xue Shi1
1Department of Ultrasound, The Second Hospital of Shandong University, No 247, Beiyuan Street, Jinan, 250033, Shandong, China.
Insights into imaging
|August 4, 2023
概括
声音触摸弹性图 (STE) 和声音触摸量化 (STQ) 可以评估慢性病 (CKD) 中的硬度. 在诊断蛋白尿症的CKD患者中,STE表现出比STQ更大的有效性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 慢性病 (CKD) 是一种影响功能的渐进性疾病.
- 评估硬度对于了解CKD进展至关重要.
- 新的成像技术为组织特征提供了非侵入性的方法.
研究的目的:
- 用声触摸弹性图 (STE) 和声触摸量化 (STQ) 来研究CKD患者的硬度.
- 将STE和STQ的诊断疗效与脏活检进行比较,作为黄金标准.
- 为了将硬度测量与CKD严重程度和生化标志物的相关性.
主要方法:
- 一项涉及60名患有蛋白尿的CKD患者和45名健康对照者的研究,在2019年1月至2022年6月期间进行.
- 使用STE和STQ测量右的最大和平均弹性模量 (Emax,Emean).
- 记录生物化学概况和脏活检结果以求相关性.
主要成果:
- STE测量 (Emax, Emean) 在CKD患者和对照人群之间显示出显著的差异.
- 经过ROC分析,STE在区分病方面比STQ (AUC 0.612-0.569) 具有更高的能力 (AUC 0.718-0.744).
- STE的Emax与血清肌素和β2-微球蛋白 (r=0.257-0.292) 有积极的相关性.
- 硬度在CKD不同病理阶段有显著差异.
结论:
- STE和STQ都是可行的,非侵入性的方法来量化硬度.
- 在诊断患有蛋白尿的CKD患者时,STE证明比STQ更有效.
- 硬度测量与CKD严重程度和关键生物标志物相关.
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